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N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

Nature proposal cover hnRNP decipher RNP code dph N6mA methyl adenosin RNA 3Dciencia

Pathogenic bacteria fight versus oxidative stress

cell host microbe proposal h2o2 bacterial proteome cover 3dciencia web

Cytochrome P450 aromatase enzyme inhibitor

La aromatasa es una enzima del tipo citocromo P450 que cataliza con alta especificidad la síntesis de estrogenos a partir de androgenos. Los inhibidores de la aromatasa como el exemestano son compuestos utilizados para el tratamiento del cáncer de mama sensible a estrógenos. En la figura se muestra el sitio de unión de este tipo de compuestos a la enzima y su inhibición. Cerca del centro activo donde se encuentra el grupo hemo que es imprescindible para la catalisis. En este caso el inhibidor es una variación del exemestano con un cola hidrofóbica más larga a la izquierda que lo hace más afin.

Alpha Carbonic Anydrase Zinc active center

IYCr2014 Dorothy Crowfoot Hodgkin

Cyclodextrin Glycosyltransferase complexed with Beta-Cyclodextrin

CDGT cyclodextrin glycosyltransferase cyclo hepta amylose beta-CD clicodextrina glicosil transferase

Mitochondrial uncoupling protein 2 (UCP2)

Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the mitochondrial anion carrier protein family, the members of which facilitate the transport of small molecules across the mitochondrial inner membrane. When the mitochondrial respiratory complex pumps protons from the mitochondrial matrix to the intermembrane space, it builds up an electrochemical potential. A fraction of this electrochemical potential is dissipated as heat, in a process involving leakage of protons back to the matrix. This leakage, or ‘uncoupling’ of the proton electrochemical potential, is mediated primarily by uncoupling proteins.

Adenine A2A receptor complexed with caffeine. GPCRc

Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved properties have been developed as potential treatments for diseases such as Parkinson’s disease.

RNA Polymerase II – TFIIB complex

Acta Chimica Sinica Cover

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