Adenine A2A receptor complexed with caffeine. GPCRc

Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved properties have been developed as potential treatments for diseases such as Parkinson’s disease.

ketamine blockade of Pentameric ligand-gated ion channel

ketamine blockade of Pentameric ligand-gated ion channel

West Nile Virus. Encephalitis

[caption id="attachment_634" align="alignnone" width="807"] West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the family Flaviviridae.[/caption]

Neurochemical cascade promoting stress-induced anxiety

Neurons

neuronas neurons network schwann cell cover bid axon myelin

Amygdala

SIRT1 in your brain.

Sirtuin 6 NAD+-dependent protein deacetylase

Molecularly, Sirt6 neural deletion results in striking hyperacetylation of histone H3 lysine 9 (H3K9) and lysine 56 (H3K56), two chromatin marks implicated in the regulation of gene activity and chromatin structure, in various brain regions including those involved in neuroendocrine regulation.

Brain slice