Pathogenic bacteria fight versus oxidative stress

Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) encountered in the host environment.

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Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria. Xin Deng · Eranthie Weerapana · Olesya Ulanovskaya · Fei Sun · Haihua Liang · Quanjiang Ji · Yan Ye · Ye Fu · Lu Zhou · Jiaxin Li · Haiyan Zhang · Chu Wang · Sophie Alvarez · Leslie M Hicks · Lefu Lan · Min Wu · Benjamin F Cravatt · Chuan He. Cell host & microbe 03/2013; 13(3):358-70. DOI:10.1016/j.chom.2013.02.004

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