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3Dciencia Visual Life Sciences

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Day: June 6, 2011

Src kinases Hck. Hematopoietic cell kinase

Human tirosine protein-kinase (C-SRC) 3D ribbon structure with phosphoaminophosphonic acid adenilate ester (ANP) bound to ATP binding site. Hematopoietic cell kinase. Src family kinases are maintained in an assembled, inactive conformation by intramolecular interactions of their SH2 and SH3 domains. Full catalytic activity requires release of these restraints as well as phosphorylation of Tyr-416 in the activation loop. Disassembly of the regulatory domains, induced by SH2 or SH3 ligands, or by dephosphorylation of Tyr-527, could lead to exposure and phosphorylation of Tyr-416.

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