Molecular biology: RNA modification does a regulatory two-step. The m6A structural modification of RNA regulates gene expression. It has now been found to mediate an unusual control mechanism: by altering the structure of RNA, m6A allows a regulatory protein to bind to that RNA.
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions. Nian Liu, Qing Dai, Guanqun Zheng, Chuan He, Marc Parisien & Tao Pan. Nature 518, 560–564 (26 February 2015) doi:10.1038/nature14234. Received 24 November 2014 Accepted 14 January 2015 Published online 25 February 2015