Sirtuin 3 deacetylase Anaglyph Sirt3

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been  linked to the beneficial  effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases.

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases.

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been  linked to the beneficial  effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases.

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases.

Situin 3 reaction intermediate structure trapped by a thioacetyl peptide.

Situin 3 reaction intermediate structure trapped by a thioacetyl peptide. PDB code 3GLT. peptide acetyl-CoA synthetase 2.

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. Lei Jin, Wentao Wei§ , Yaobin Jiang, Hao Peng, Jianhua Cai, Chen Mao, Han Dai, Wendy Choy, Jean E. Bemis, Michael R. Jirousek, Jill C. Milne, Christoph H. Westphal and Robert B. Perni.

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